Harmful behaviour through plasmid transfer: a successful evolutionary strategy of bacteria harbouring conjugative plasmids

  • Articles in SCI Journals
  • Mar, 2022

Domingues, C.P.F., Rebelo, J.S., Monteiro, F., Nogueira, T. & Dionisio, F. (2022) Harmful Behaviour through Plasmid Transfer: A Successful Evolutionary Strategy of Bacteria Harbouring Conjugative Plasmids.

Philosophical Transactions of The Royal Society of London Series B-Biological Sciences, 377, 1842. DOI:10.1098/rstb.2020.0473 (IF2022 3,586; Q1 Biology)
Summary:

Conjugative plasmids are extrachromosomal mobile genetic elements pervasive among bacteria. Plasmids' acquisition often lowers cells' growth rate, so their ubiquity has been a matter of debate. Chromosomes occasionally mutate, rendering plasmids cost-free. However, these compensatory mutations typically take hundreds of generations to appear after plasmid arrival. By then, it could be too late to compete with fast-growing plasmid-free cells successfully. Moreover, arriving plasmids would have to wait hundreds of generations for compensatory mutations to appear in the chromosome of their new host. We hypothesize that plasmid-donor cells may use the plasmid as a ‘weapon’ to compete with plasmid-free cells, particularly in structured environments. Cells already adapted to plasmids may increase their inclusive fitness through plasmid transfer to impose a cost to nearby plasmid-free cells and increase the replication opportunities of nearby relatives. A mathematical model suggests conditions under which the proposed hypothesis works, and computer simulations tested the long-term plasmid maintenance. Our hypothesis explains the maintenance of conjugative plasmids not coding for beneficial genes.

This article is part of the theme issue ‘The secret lives of microbial mobile genetic elements’.


https://royalsocietypublishing.org/doi/10.1098/rstb.2020.0473

Team

  • Harmful behaviour through plasmid transfer: a successful evolutionary strategy of bacteria harbouring conjugative plasmids Célia Ferreira Domingues Evolutionary Ecology - EE
  • Harmful behaviour through plasmid transfer: a successful evolutionary strategy of bacteria harbouring conjugative plasmids Célia Ferreira Domingues Evolutionary Genetics - EG
  • Harmful behaviour through plasmid transfer: a successful evolutionary strategy of bacteria harbouring conjugative plasmids Francisca Monteiro Evolutionary Ecology - EE
  • Harmful behaviour through plasmid transfer: a successful evolutionary strategy of bacteria harbouring conjugative plasmids Francisco Dionísio Evolutionary Ecology - EE
  • Harmful behaviour through plasmid transfer: a successful evolutionary strategy of bacteria harbouring conjugative plasmids João Santos Rebelo Evolutionary Ecology - EE
  • Harmful behaviour through plasmid transfer: a successful evolutionary strategy of bacteria harbouring conjugative plasmids Teresa Nogueira Microbial Genomics and Bioinformatics