Madureira, A.M. & Teixeira, G. (2022) Survey of the In Vitro Antifungal Activity of Paeonia broteri Extracts.Journal of Pharmacy and Pharmaceutical Sciences, 9(5), 555775. DOI:10.19080/GJPPS.2022.09.555775 (IF2021 3,337; Q3 Pharmacology & Pharmacy)
Objective: Some species of Paeonia are widely studied as they are used in traditional Chinese medicine as an anti-inflammatory, antioxidant, antitumor, immune-system-modulation and antiseptic. There is still a lack of knowledge about other temperate Eurasia species. Such is the case of P. broteri, an Iberian endemism whose preliminary studies have the purpose to evaluate antifungal properties of their roots, leaves and fruits extracts.
Methods: The microdilution method was used to evaluate the minimum inhibitory concentration (MIC) of P. broteri extracts against 13 selected fungi and yeasts: Aspergillus niger, Candida albicans, C. dubliniensis, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis, C. tropicalis, Cryptococcus neoformans, Geotrichum sp., Rhodotorula rubra, Saccharomyces cerevisiae and Trichosporon cutaneum. P. broteri extracts where obtained by sequential extraction of increasing polarity (n-hexane, CH2 Cl2 , EtOAc, MeOH and H2O) and their phytochemical profile was screened.
Results: P. broteri roots and leaves extracts were the most active, in particular against Geotrichum sp, T. cutaneum and A. niger. The chemical profile of these extracts, flavonoids, phenols and terpenoids, may be responsible for their antifungal activity.
Conclusion: Studies with P. broteri extracts indicate that they may have antifungal potential.