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Development and Evolutionary Morphogenesis - DEM

Bárbara Caldeira Bairrão Ruivo

MSc Student

I am a MSc student in Evolutionary and Developmental Biology, at the Faculty of Sciences (Universidade de Lisboa). I am currently working on my MSc thesis project under the supervision of Prof. Dr. Sólveig Thorsteinsdóttir, in the Developmental and Evolutionary Morphogenesis (DEM) group of the CE3C. Our main focus of research is a disease called Merosin-deficient Congenital Muscular Dystrophy type 1A, which is the most common Congenital Muscular Dystrophy in Europe.  My project "Understanding MDC1A onset: a study of the effect of laminin 211-deficiency on myofibers and muscle stem cells" aims to understand fetal MuSC behavior when in contact with a deficient myofiber niche. The objective is to compare division/differentiation dynamics and proliferation rates of MuSCs and myogenic cells between wild type and dystrophic mouse fetuses.



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