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Development and Evolutionary Morphogenesis - DEM

André Brás Gonçalves

PhD Student

André Brás Gonçalves is conducting a Ph.D. in Developmental Biology by the University of Lisbon starting in 2013 within the Development and Evolutionary Morphogenesis group of cE3c. He is conducting the project “Organizing axial muscles: crosstalk between the myotome and myogenic precursor cells in constructing the muscles of the back”, under the supervision of Dr. Sólveig Thorsteinsdóttir and Dr. Marianne Deries from the University of Lisbon. André Brás Gonçalves project aims are:

- Study the embryonic vertebrate development, focusing on how the extracellular matrix (ECM) and cell-ECM interactions influence cell differentiation and cell behavior during development with particular emphasis on the morphogenesis of mesodermal derivatives.

- Address how the nature of the ECM contributes to developmentally controlled mesenchyme-to-epithelium and epithelium-to-mesenchyme cellular transitions during skeletal myogenesis and how the ECM affects the development skeletal muscle morphogenesis in the mouse embryo.

 – Address how the development of back muscles of terrestrial vertebrates differ from the aquatic vertebrates.

- Determine whether the ECM environment surrounding embryonic progenitor cells in the embryo (e.g. precursor of skeletal muscle) regulates their decision to remain proliferative or enter their differentiation programs.